In this presentation, I will delve into the transformative potential of CAR T cell therapy in the field of solid tumours. Beginning with an overview of CAR T cell therapy and its impact on cancer treatment, I will navigate through the distinct challenges posed by solid tumours, including their heterogeneity and the complexities of the tumour microenvironment. I will spotlight breakthroughs in preclinical and clinical trials demonstrating the feasibility and efficacy of CAR T cells against solid tumours, while also addressing toxicity considerations. This presentation also explores strategies to enhance CAR T cell efficacy within the tumour microenvironment. Looking ahead, I will describe the potential future of CAR T cell therapy in solid tumours with optimisation through collaborative efforts, innovative designs, and combination therapies.